It's really interesting here..! This week Stem Cells, there is an interesting paper! A research group has found that the proto-oncogene kinase pim-1 and pim-3 (in detail: Serine/threonine protein kinases -> CAMK group -> PIM family -> proto-oncogene serine/threonine-protein kinase Pim-1 and Pim-3) plays important role in stem-cell renewal!!
The authors have demonstrated a novel role of proto oncogene Pim 1 and 3 in ES self-renewal as well as exhibited resistance to leukemia inhibitory factor (LIF) starvation, a gp130 family cytokines proteins, which is also regulating the subsequent protein, Stat3 (Signal Transducer and Activator of Transcription 3).
Irène Aksoy etal Self-Renewal of Murine Embryonic Stem Cells Is Supported by the Serine/Threonine Kinases Pim-1 and Pim-3 Stem Cells (December 2007; Vol. 25, No. 12, pp. 2996 -3004).
The most curiosities and surprising part is that , until this time (including the previous (post)surveying on the Serine/threonine protein kinases in (stem cell niche/stromal-fibroblast cell– microenvironment) I used to think that the Serine/threonine kinase protein means it’s always only meant for aberrant expressions or for druggable targets, preferably for cancer.....! So seems like the paper are igniting an additional, the most exciting way of thinking on the field of serine/threonine kinase families proteins …!
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