In order to have an overview on the field of stem-cell biology, I have found about 147947 references on the web site, Entrez while typing the key word stem-cells.
My initial thought is that I am going to walk in between a mountain. But once I have started to read few pages of the abstracts, immensely its guided me to have some idea and ignited me to start to read from the area of ‘stem-cell niche’ or microenvironment because of their remarkable cellular / physiological functions. Such as
- Acting as ‘specific anatomic locations’ that regulate tissue generation, maintenance and repair,
- ‘saves stem cells’ from depletion, while protecting the host from over-exuberant stem-cell proliferation,
- ‘acting as a reservoir’ for residual (cancer) stem / quiescent cells followed by opportunities to design stem-cell therapeutics, as well as
- ‘An associated steps’ for further cellular process such as self renewal and differentiation.
(did I miss any points here..?)
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