A subset of neoplastic cells , in the cancer stem-cells niche/microenvironment, has features that not only sustain glioma growth but may also confer resistance to standard glioma treatments. At the very basic level, however, whether glioma stem cells derive from indigenous neural stem cells (NSC), or from tumor cells that have reacquired stem cell-like properties, is still unknown. In this thrilling phase, report from Moses group demonstrating in vivo that the infiltrating tumor cells may arise from NSC transformed by activation of oncogenic K-ras.
One Year Ago….:
In medulloblastoma, Hambardzumyan and colleagues demonstrated in vivo that PI3K signaling pathway regulates survival of cancer stem cells residing in the perivascular niche following the radiation
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