According to the osteoblastic niche model, which was originally proposed by Scadden and Linheng Li, the hematopoietic stem cells (HSCs) are maintained by the junction protein called N-cadherin-mediated homophilic adhesion to osteoblasts at the bone marrow endosteum. In contrast to this model, recent report from Sean Morrison group demonstrating that the N-cadherin expression by HSCs is not necessary for niche function. Extending this surprise results they have also demonstrated that N-cadherin deficiency did not affect bone marrow cellularity or lineage composition, the numbers of colony-forming progenitors, the frequency of HSCs, the ability of HSCs to sustain hematopoiesis over time, or their ability to reconstitute irradiated mice in primary or secondary transplants. This is quite interesting reports.
One Year Ago….:
Linheng Li and colleagues reveal differential N-cadherin expression reflects functional distinctions between two HSC subpopulations i.e., reserved versus primed states of hematopoietic stem cells.
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